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. 2019 Sep 18;17:123. doi: 10.1186/s12964-019-0436-1

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© The Author(s). 2019

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — C. elegans and human peptide alignment. Amino acid sequences of C. elegans and human peptides aligned to the amidated C terminus (a-amide, conserved C-terminal RF/Ya and additional R at − 4 position highlighted in black rectangles). C. elegans peptide syntax consists of gene and isoform. Amino acids are colored according to their properties (Lesk scheme [26])