Figure 3. Association of Higher Fluorine F 18–Labeled N-(2-(2-fluoroethoxy)benzyl)-N-(4-phenoxypyridin-3-yl)acetamide ([¹⁸F]FEPPA) Distribution Volume With Lower 11-Nor-9-carboxy-Δ9-tetrahydrocannabinol (COOH-THC) Metabolite Levels in Blood Serum of Long-term Cannabis Users.

The associations, adjusted for translocator protein rs6971 genotype (high-affinity binders [HAB] or mixed-affinity binders [MAB]), are shown for the dorsolateral prefrontal cortex (DLPFC: r = –0.6; P = .03) (A) and medial prefrontal cortex (mPFC: r = –0.7; P = .007) (B). Similar correlations were present in the temporal cortex (r = –0.6; P = .02) and anterior cingulate cortex (r = –0.6; P = .02).