Table 1.
Clinicpathological parameters associated with AFR in advanced EOC patients
| AFR | |||
|---|---|---|---|
| Parameters | Low (≤7.78) | High (> 7.78) | p value |
| Number | 151 | 162 | – |
| Age (years) | 65.8 ± 8.7 | 63.1 ± 7.8 | 0.004* |
| BMI (kg/m2) | 23.1 ± 2.3 | 23.4 ± 2.1 | 0.229 |
| Current smokers (n, %) | 18 (11.9) | 24 (14.8) | 0.453 |
| Alcohol (n, %) | 14 (9.3) | 19 (11.7) | 0.479 |
| Comorbidities (n, %) | – | ||
| Diabetes | 22 (14.6) | 17 (10.5) | 0.275 |
| Hypertension | 27 (17.9) | 22 (13.6) | 0.295 |
| Hyperlipemia | 15 (9.9) | 12 (7.4) | 0.426 |
| Histological grade (n, %) | 0.042* | ||
| G1 | 76 (50.3) | 100 (61.7) | – |
| G2/3 | 75 (49.7) | 62 (38.3) | – |
| Histological type (n, %) | 0.444 | ||
| Serous | 106 (70.2) | 120 (74.1) | – |
| Non-serous | 45 (29.8) | 42 (25.9) | – |
| FIGO stage (n, %) | 0.032* | ||
| III | 113 (74.8) | 137 (84.6) | – |
| IV | 38 (25.2) | 25 (15.4) | – |
| ECOG PS (n, %) | 0.016* | ||
| 0 | 101 (66.9) | 128 (79.0) | – |
| ≥ 1 | 50 (33.1) | 34 (21.0) | – |
| Chemotherapy resistance (n, %) | 54 (35.8) | 40 (24.7) | 0.033* |
| Residual tumor (cm) | 0.005* | ||
| ≤ 1 | 100 (66.2) | 130 (80.2) | – |
| > 1 | 51 (33.8) | 32 (19.8) | – |
EOC, Epithelial ovarian cancer; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status. P-values were calculated by Student’s t test, Mann–Whitney U test or Chi-squared test. * P < 0.05.