Table 4.
Risk factors for OS by univariate and multiple Cox analysis
| Univariate | Multivariate | |||
|---|---|---|---|---|
| Parameters | HR(95% CI) | p value | HR(95% CI) | p value |
| Age (high vs low) | 1.23 (0.84–1.81) | 0.304 | ||
| BMI (high vs low) | 0.53 (0.24–1.15) | 0.112 | ||
| Current smokers (yes vs no) | 1.09 (0.76–1.57) | 0.647 | ||
| Alcohol (yes vs no) | 1.17 (0.82–1.67) | 0.384 | ||
| Diabetes (yes vs no) | 1.24 (0.71–2.13) | 0.435 | ||
| Hypertension (yes vs no) | 1.31 (0.83–2.05) | 0.247 | ||
| Hyperlipemia (yes vs no) | 0.85 (0.54–1.33) | 0.468 | ||
| Histological grade (G2/3 vs G1) | 1.57 (1.03–2.41) | 0.034* | 0.92 (0.81–1.22) | 0.068 |
| Histological type (serous vs non-serous) | 0.49 (0.83–2.64) | 0.181 | ||
| FIGO stage (IV vs III) | 1.89 (1.17–3.11) | 0.014* | 1.58 (0.77–3.35) | 0.221 |
| ECOG PS (≥1 vs 0) | 1.12 (0.74–1.69) | 0.603 | ||
| Chemotherapy resistance (yes vs no) | 1.27 (1.03–1.62) | 0.021* | 1.30 (1.01–1.67) | 0.032* |
| Residual tumor (> 1 cm vs ≤1 cm) | 1.32 (1.04–1.68) | 0.022* | 1.48 (1.01–2.21) | 0.046* |
| Hemoglobin (high vs low) | 0.78 (0.39–1.56) | 0.478 | ||
| Platelet (high vs low) | 1.55 (0.75–3.18) | 0.237 | ||
| WBC (high vs low) | 1.39 (0.77–2.51) | 0.278 | ||
| Albumin (high vs low) | 0.65 (0.38–1.12) | 0.112 | ||
| Total protein (high vs low) | 0.89 (0.55–1.45) | 0.642 | ||
| Total cholesterol (high vs low) | 0.69 (0.31–1.52) | 0.359 | ||
| Triglyceride (high vs low) | 1.50 (0.83–2.73) | 0.181 | ||
| CA125 (high vs low) | 1.41 (0.73–2.73) | 0.304 | ||
| CRP (high vs low) | 1.17 (0.64–2.11) | 0.613 | ||
| AFR (≤7.78 vs > 7.78) | 2.50 (1.44–4.09) | 0.007* | 2.19 (1.18–3.67) | 0.021* |
EOC, Epithelial ovarian cancer; OS, Orall survival; BMI, Body mass index; FIGO, International Federation of Gynecology and Obstetrics; AFR, Albumin-to-fibrinogen ratio; ECOG PS, Eastern cooperative oncology group performance status; WBC, White blood cell; CRP, C-reactive protein; HR, Hazard ratio; CI, Confidence interval. * P < 0.05.