Table 4.
Subgroup Analysis: Change in lung function and BMI over time (post-lung resection) by sex (n = 39) and by extent of lung resection (n = 35)
| Outcome | Subgroup | Intercept (95% CI) | p-value | Change per year (95% CI) |
p-value* |
|---|---|---|---|---|---|
| FVC Z score | Males | −0.68 | 0.125 | −0.049 | 0.263 |
| (−1.57, 0.22) | (−0.09, − 0.01) | ||||
| Females | −1.65 | −0.021 | |||
| (−3.79, 0.49) | (−0.11, 0.07) | ||||
| FEV1 Z score | Males | −0.94 | 0.064 | −0.08 | 0.026 |
| (−1.71, −0.17) | (−0.12, − 0.05) | ||||
| Females | −1.96 | −0.03 | |||
| (−3.81, −0.11) | (−0.11, 0.04) | ||||
| BMI Z score | Males | −0.04 | 0.180 | 0.02 | 0.967 |
| (−0.71, 0.62) | (−0.01, 0.05) | ||||
| Females | −0.68 | 0.02 | |||
| (−2.27, −0.92) | (−0.05, 0.09) | ||||
| FVC Z score | Single Lobe | −0.75 | 0.040 | −0.03 | 0.645 |
| (−1.38, −0.13) | (−0.06, − 0.01) | ||||
| Multiple Lobes | −2.49 | −0.05 | |||
| (−4.79, −0.21) | (−0.14, 0.04) | ||||
| FEV1 Z score | Single Lobe | −1.10 | 0.012 | −0.06 | 0.955 |
| (−1.61, −0.60) | (−0.08, − 0.03) | ||||
| Multiple Lobes | −2.89 | −0.06 | |||
| (−4.78, −0.99) | (−0.14, 0.02) | ||||
| BMI Z score | Single Lobe | −0.15 | 0.456 | 0.02 | 0.042 |
| (−0.64, 0.35) | (0.01, 0.04) | ||||
| Multiple Lobes | −0.62 | −0.02 | |||
| (−2.35, 1.12) | (−0.08, 0.04) |
*P value for interaction, testing whether the relationship between independent variables (FVC, FEV1, BMI) and time is different within the lobectomised patients between males and females (Subgroup Analysis 1) and between single and multiple lobes resected (Subgroup Analysis 2)