Table 3.
Univariate and multivariate analysis of RFS in LUAD.
| Parameters | Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|---|
| p | HR | 95% CI (lower/upper) | p | HR | 95% CI (lower/upper) | |||
| Age (Continuous) | 0.356 | 1.008 | 0.991 | 1.025 | ||||
| Gender | ||||||||
| Male (N=191) | 1.000 | |||||||
| Female (N=233) | 0.516 | 1.114 | 0.805 | 1.541 | ||||
| Smoking history | ||||||||
| 2/3/4/5 (N=345) | 1.000 | |||||||
| 1 (N=65) | 0.454 | 1.199 | 0.746 | 1.926 | ||||
| Pathological T stages | ||||||||
| T3/T4 (N=46) | 1.000 | |||||||
| T1/T2 (N=375) | 0.002 | 0.468 | 0.291 | 0.754 | 0.018 | 0.546 | 0.330 | 0.903 |
| Pathological N stages | ||||||||
| N1/N2/N3 (N=133) | 1.000 | |||||||
| N0 (N=279) | 0.005 | 0.622 | 0.448 | 0.863 | 0.062 | 0.685 | 0.460 | 1.020 |
| Pathological stages | ||||||||
| III/IV (N=80) | 1.000 | |||||||
| I/II (N=337) | 0.009 | 0.599 | 0.407 | 0.882 | 0.519 | 0.849 | 0.517 | 1.396 |
| Residual tumors | ||||||||
| Yes (N=12) | 1.000 | |||||||
| No (N=273) | 0.000 | 0.262 | 0.126 | 0.543 | ||||
| Mutation in KRAS/EGFR/ALK | ||||||||
| Yes (N=77) | 1.000 | |||||||
| No (N=108) | 0.787 | 1.063 | 0.684 | 1.653 | ||||
| SUMO1 expression | 0.095 | 1.342 | 0.950 | 1.898 | ||||
| SUMO1P3 expression | 0.016 | 1.451 | 1.073 | 1.962 | 0.027 | 1.418 | 1.041 | 1.930 |
Smoking history: 1 – lifelong non-smoker; 2 – current smoker; 3 – current reformed smoker (for >15 yrs); 4 – Current reformed smoker (for ≤15 yrs); 5 – Current reformed smoker (duration not specified); NX – regional lymph nodes cannot be assessed; RX – the presence of residual tumor cannot be assessed.