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. 2019 Sep;5(3):308–319. doi: 10.18383/j.tom.2019.00015

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© 2019 The Authors. Published by Grapho Publications, LLC

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Figure 3. — R2* enhancement affects accuracy of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters. Median K^trans (A), v_e (B), and v_p (C) values without (uncorr) and with correction for R2* relaxation (R2*-corr) for each TOV-21G ovarian tumor xenograft (blue circles) and TRAMP mouse prostate (red triangles). Paired t tests were performed to compare uncorrected and R2*-corrected values, and P values were corrected for multiple comparisons using the Benjamini–Hochberg procedure. Median percent errors (uncorrected vs R2*-corrected) of Tofts parameter estimates (D). A 2-way ANOVA and Tukey honest significant difference post hoc tests were performed to compare the errors in different parameters in different tissues (*P < .05, **P < .001, ***P < .0001).