Fig. 2. Mutations in NOTCH3  EGFr domains  1–6 are associated with a higher nWMHV than mutations in  EGFr domains  7–34 .

Scatterplot showing the correlation between normalized white matter hyperintensity volume (nWMHV) and age, stratified according to epidermal growth factor-like repeat (EGFr) group. Diagnosed CADASIL patients with a mutation in one of EGFr domains 1–6 have a higher nWMHV than patients with a mutation in one of EGFr domains 7–34