Fig. 4. Characteristics of the three groups created by our classifiers.

a Group-specific means (+/- SEM) for analogous features (upper panel), and intragroup distribution of states for digital features (lower panel). Note that for the majority of features, the variants that require Sanger sequencing occupy an intermediate position. b Performance of filtering criteria in the set of variants that require Sanger-based confirmation (compare Fig. 1a, b)