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. 2019 Feb 28;21(9):1931–1939. doi: 10.1038/s41436-019-0466-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Impact of different 1-in-100 carrier rate threshold definitions on carrier rates and at-risk couple rates. Included conditions met the first six American College of Obstetricians and Gynecologists (ACOG) criteria (Fig. 1) and different definitions of the 1-in-100 carrier rate ACOG criteria (x-axis). Shading of green bars denotes different carrier rate thresholds for X-linked conditions: a carrier rate threshold of 1 in 100 (light green) and a carrier rate threshold of 1 in 10,000 (dark green). (a) The number of diseases that meet criteria. (b) US-weighted panel carrier rates. (c) US-weighted at-risk couple rates. (d) The number of observed at-risk couples that would be identified by the panel subset. Specific conditions of observed at-risk couples are shown in Figure S1. Horizontal lines show respective numbers for the 176-condition panel.