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. 2019 Feb 28;21(9):1931–1939. doi: 10.1038/s41436-019-0466-5

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© The Author(s) 2019

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Fig. 4 — The relationship between panel size, panel carrier rate, and at-risk couple rate. (a) The panel carrier rate (green) and panel at-risk couple rate (purple) are plotted as a function of the carrier rate threshold and panel size (x-axis). Conditions are ordered from most to least prevalent based on US-weighted carrier rate. Because X-linked and autosomal recessive (AR) conditions are inherited differently, carrier rates for X-linked conditions were transformed to corresponding AR carrier rates based on their at-risk couple rates. For example, for an X-linked condition with a carrier rate and at-risk couple rate of 1 in 10,000, the carrier rate would be transformed to 1 in 100. (b) Ratio of marginal panel carrier rate to marginal at-risk couple rate as a function of the panel size determined by carrier rate threshold (x-axis). The panel carrier rate was calculated from condition-specific US-weighted carrier rates. At-risk couple rates were calculated as the square of the US-weighted carrier rate.