Table 2.

Overview of the statistical analysis on the facial similarity between individuals with a missense variant of uncertain significance in the PHIP gene and individuals with a presumed loss-of-function variant in the PHIP gene (one-sided Mann–Whitney U test)

ID	Distance to nearest PHIP patient	Median distance of controls to nearest PHIP patient	U statistic	p value
Individual A	1.147	1.557	0	<1.52 × 10−2a
Individual B	1.390	1.557	11	1.82 × 10−1
Individual C	1.300	1.554	3	6.06 × 10−2
Individual D	1.138	1.557	0	<1.52 × 10−2a

^aStatistically significant difference.