Figure 2.

WGCNA analysis indicates that KIAA1199 is involved in cell migration and invasion. (A) Cluster dendrogram trees were constructed based on the whole-genome profiling data of TCGA. (B) Heatmap of the relationships between clinical traits and gene modules, and the brown module with highest correlation value (r=0.48, p=8e-20) was chosen for further study. (C) A significant correlation was found between module membership and gene significance of KIAA1199 in the brown module. (D) The major part of the KIAA1199-related network was labelled as “cell adhesion/cell migration/exocytosis/chemotaxis/ECM organization”, which are critical events in cancer invasion and metastasis.