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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Mol Pharm. 2019 Jul 30;16(9):4017–4023. doi: 10.1021/acs.molpharmaceut.9b00671

Table 1.

Nitric oxide-release properties of HP-PO/NO polymers at pH 7.4, 37 °C.a

PBS W-C Broth
t[NO]
(μmol/mg)b
t1/2
(min)c
duration
(h)d
t[NO]
(μmol/mg)b
t1/2
(min)c
duration
(h)d
1.11 ± 0.18 54 ± 5 14.0 ± 2.0 1.04 ± 0.23 19 ± 3 6.8 ± 1.0
a

n ≥ 3 separate syntheses;

b

The total NO payloads (μmol NO per mg of polymer);

c

Time to release half of NO totals.

d

Time to reach the measured NO level ≤ 10 PPB mg−1 s−1.