Table 2.

The absolute amounts and their corresponding local concentrations, doses, and therapeutic NO amounts of the HP-PO polymers tested in the study.

Absolute amount (μg)a	Concentration in PBS (mg/mL)b	Concentration in the chamber (mg/mL)c	Dose (mg/kg)d	Therapeutic NO amount (μg/kg)e
30	1	0.3	1.5	47
150	5	1.5	7.5	234
750	25	7.5	37.5	1170

^aThe absolute mass of the polymers injected into the chambers;

^bThe concentration of polymers in the delivery vehicle (i.e., 30 μL of PBS);

^cThe estimated concentration of polymers in the chamber (i.e., 100 μL) after injection;

^dThe amount of polymers injected into the chambers normalized to the mass of the mice (20 g);

^eThe amount of NO delivered into the chambers, which was estimated by multiplying the NO totals of HP-PO/NO polymers measured in the broth (Table 1) with the tested doses.