Table 3 –

Selected studies evaluating abdominal thromboses in pancreas ductal adenocarcinoma ( N=10 )

Author/ Year/ Reference	Study Design	No of Subjects	Country	Vein Location	Age (mean)	Histology	Primary working hypothesis	Observations
Dedania N et al. 2013	Retrospective study	SVT =19	USA	Splenic vein	62.2	Pancreas adeno carcinoma	SVT is associated with increase intraoperative blood loss, pancreas specific complications and reduced long term survival cross-sectional study to determine the prevalence of asymptomatic (incidental) venous thromboembolism seen on staging CT scans, in a consecutive series of patients.	Retrospective study evaluating surgical complications after distal pancreatectomy in PAC
Douma et al. 2015	Retrospective study	T= 9 PVT=5 SVT=3 RVT=1	USA	Portal, Renal and Mesenteric	57	Pancreas adeno carcinoma		A second objective was to assess the subsequent therapeutic implications of these thrombi.
Kawaka mi H et al. 2007	Case report	1	Japan	Portal Vein	68	Pancreas adeno carcinoma	EUS was helpful to delineate the intraportal growth of the tumor, and ERP to delineate the intraductal growth of the tumor.	tumor with intraductal growth into the main pancreatic duct that presented with tumor thrombus in the portal vein.
Menapac e LA et al. 2011	Retrospective study	T= 45 PVT=18 SVT=14 MVT=13	USA	Portal, Splenic and Mesenteric	65.9	Pancreas adeno carcinoma	Determine the prevalence of both symptomatic and incidental VTE in patients with PAC	Large study that assessed for visceral thrombosis on PAC. Incidentally discovered visceral vein thrombi are associated with worsened mortality and clinical consequences who may benefit from therapeutic anticoagulation.
Onesti JK et al. 2013	Retrospective study	SVT=2	USA	Splenic Vein	61	Pancreas adeno carcinoma	Analysis of the pathologic implication of splenectomy in suspected distal pancreatic malignancy.	Only 2 patients were noted to have splenic vein thrombosis.
Roch AM et al. 2015	Retrospective study	26	USA	Splenic Vein	65.4	Pancreas adeno carcinoma	Extended distal pancreatectomy for locally advanced adenocarcinoma is associated with a survival benefit.	Single institution retrospective study, long study period from 1996-2011.
Roldan-Valadez E et al. 2008	Case report	1	Mexico	Portal Vein	68	Pancreas adeno carcinoma	Patient with PAC with clinical findings of portal hypertension who underwent PET/CT with finding of PVT.	PVT did not show enhancement or neovascularity with contrast CT, with the possibility of a bland tumor from altered portal venous hemodynamics.
Søgaard KK et all. 2015	Retrospective study	T= 20 PVT=19 HVT=1	Denmark	PVT, HVT	61	Pancreas adeno carcinoma	Examined cancer risk after a first time SVT diagnosis, comparing cancer risk with the general Danish population, in addition to comparing survival among patient with and without SVT	Final conclusion: study found evidence that SVT is a strong marker of occult cancer and a predictor of poor prognosis for patients with liver and pancreatic cancer.
Venturi A et al. 2007	Case report	1	Italy	Portal vein	64	Pancreas adeno carcinoma	CEUS is reliable, non-invasive and useful diagnostic technique in the differential diagnosis between benign and malignant PVT outside the setting of chronic liver disease.	This case report evaluated the role of real-time Contrast-enhance ultrasound(CEUS) in the assessment of PVT
Yamato H et al. 2009	Care Reports	2	japan	1.Portal Vein 2.inferior Mesenteric Vein	66	2: Pancreas tubular Adeno carcinoma	Case 1: underwent surgical resection, 14 months after surgery thrombus extended into SMV, patient was alive 19months after surgery. Case 2: surgical exertion performed, tumor recurrence 4 months after, patient died of liver failure. patient developed acute MVT-PVT on the first postoperative day, was treated with aggressive anticoagulation and early operative thrombectomy with SMV-PV reconstruction.	Description of three case reports of pancreatic carcinoma, one case was omitted due to tumor histology(endocrine carcinoma)
Zyromski NJ et al. 2008	Case report	1	USA	Mesenteric Vein Thrombosis	69	Pancreas adeno carcinoma		Case report to express awareness of early postoperative SMV-PV thrombosis after pancreaticoduodenectomy and its catastrophic complications.

SVT=splenic vein thrombosis(N=62), PVT=portal vein thrombosis(N=41), MVT=mesenteric vein thrombosis(N=15) PAC=pancreas adenocarcinoma, HVT=Hepatic vein thrombosis (N=1) T=total