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. 2019 Aug 29;3(9):nzz101. doi: 10.1093/cdn/nzz101

FIGURE 2.

FIGURE 2

Potential pan-reactivity of epigallocatechin-3-gallate (EGCG). EGCG is one of the Pan-Assay INterference compoundS (PAINS) and contains a PAINS motif, catechol, that frequently triggers signals in various bioassays by different mechanisms. For example, catechol can undergo redox cycling that causes formation of reactive chelators or orthoquinones, which subsequently modify proteins, nucleic acids, or lipids.