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. 2019 Feb 7;21(9):2145–2150. doi: 10.1038/s41436-019-0448-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, and provide a link to the Creative Commons license. You do not have permission under this license to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 1 — (a) Genetic variants detected in the NUDT15 gene region in patients with severe thiopurine-related toxicity. Dark gray arrows indicate variants resulting in variation of the NUDT15 protein sequence. Boxes indicate exons 1–3, and untranslated regions are shown in black. (b) Allele frequency of NUDT15 variants in patients with thiopurine-induced toxicity and individuals of European (non-Finnish) ancestry extracted from the Genome Aggregation Database (gnomAD)¹⁴ (see Table S3). P values indicate significant differences in genotype frequency as tested by the Armitage’s trend test. ^aVariants are not reported in exome or genome sequencing data of gnomAD.¹⁴ (c) Pie chart illustrates percentage of patients with variation in TPMT or NUDT15 genetics as well as percentage of patients with allopurinol treatment. Left part shows fractions in all patients (n = 107), whereas fractions in patients (n = 47) who developed toxicity within 3 months after the first administration of therapy are illustrated on the right.