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. 2019 Sep 19;14(9):e0222506. doi: 10.1371/journal.pone.0222506

Table 2. Clinical features of 181 subjects.

Clinical Suspicion N° of Subjects %
Marfan Syndrome (MFS) 107 59.13
Ehler-Danlos Syndrome (EDS) 34 18.79
Uncertain 22 12.15
Thoracic Aortic Aneurysm and Dissection (TAAD) 10 5.52
Bicuspid Aortic Valve (BAV) 6 3.31
Loeys-Dietz Syndrome (LDS) 1 0.55
Mass Phenotype (MASS) 1 0.55
Total 181 100
Clinical signs N° of Subjects %
Wrist sign 113 62.4
Hyperlaxity 100 55.2
Stretch marks 92 50.8
Arachnodactily 90 49.7
Mitral valve prolapse 86 47.5
Scoliosis 85 47
Flatfoot 83 45.9
Thumb sign 79 43.6
Aortic ectasia 70 38.7
Myopia 64 35.4
Pectus carinatum 33 18.2
Ectopia lentis 28 15.5
Aortic dissection 18 9.9
Reduced elbow extension 13 7.2
Major Criteria N° of Subjects %
Cardiac 87 48.1
Ocular 80 44.2
Skeletal 57 31.5
Systemic Score 28 15.5