Table 6. Sensitivity, specificity and predictive values of various case definitions for influenza virus positivity among HIV-uninfected and HIV-infected children aged <5 years hospitalised with severe respiratory illness at the Edendale and Klerksdorp hospitals, South Africa, 2011–2015.
| Value (%) and 95% Confidence Interval | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIV-uninfected | HIV-infected | All | ||||||||||
| Sensitivity | Specificity | PPV* | NPV** | Sensitivity | Specificity | PPV* | NPV** | Sensitivity | Specificity | PPV* | NPV** | |
| Various case definitions | ||||||||||||
| 2011WHO | 66 (56–76) | 32 (29–34) | 6 (5–7) | 94 (91–96) | 63 (35–85) | 31 (26–37) | 5 (2–9) | 94 (87–98) | 66 (56–74) | 32 (30–34) | 6 (5–7) | 94 (91–96) |
| 2014WHO | 66 (56–76) | 46 (44–48) | 6 (5–8) | 96 (95–97) | 63 (35–84) | 42 (36–48) | 6 (3–10) | 95 (90–98) | 66 (56–74) | 45 (43–47) | 6 (5–8) | 96 (95–97) |
| 2014WHO (fever≥38)# | 48 (38–58) | 70 (68–73) | 8 (6–11) | 96 (95–97) | 44 (20–70) | 61 (55–67) | 6 (2–12) | 95 (91–98) | 47 (38–57) | 69 (67–71) | 8 (6–10) | 96 (95–97) |
*PPV: positive predictive value.
**NPV: negative predictive value
#Documented fever and cough.