Fig 1. Effect of UFT, CTX and UFT+CTX metronomic chemotherapy on localized primary tumors.

231/LM2-4 human breast metastatic variant cells were orthotopically injected into the right inguinal mammary fat pad of 6–8 week-old female SCID mice. When tumors reached volumes of ~160–190 mm³, treatment with vehicle control 0.1% HPMC orally daily (black), 15 mg/Kg/d UFT by gavage (red), 20 mg/Kg/d CTX through the drinking water (green) or the combination UFT+CTX treatment (blue) was initiated. Primary tumors were surgically removed when they reached an average size of approximately 1,300 mm³.