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. 2019 Sep 19;14(9):e0222598. doi: 10.1371/journal.pone.0222598

Table 2. Clinical characteristics of study subjects with and without bacteremia.

No Bacteremia (n = 92) Bacteremia (n = 26) P
Total counts (cells/1 mL-blood) 0 5.1 ± 4.9
Clinical factors
    Sex (male/female) 58/34 17/9 0.826
    Age (years) 63.6 ± 9.7 64.0 ± 9.7 0.935
    Duration of diabetes (years) 13.6 ± 9.9 12.3 ± 7.6 0.828
    Body mass index (kg/m2) 25.4 ± 4.3 25.5 ± 4.3 0.843
    Fasting blood glucose (mg/dL) 135.9 ± 31.4 155.3 ± 47.2 0.065
    HbA1c (%) 7.7 ± 1.3 7.7 ± 1.3 0.896
    C-peptide (ng/mL) 1.8 ± 0.8 2.0 ± 0.7 0.211
    LDL-C (mg/dL) 114.1 ± 30.0 112.1 ± 38.2 0.432
    HDL-C (mg/dL) 51.4 ± 15.2 51.5 ± 14.2 0.826
    TG (mg/dL) 113.6 ± 47.8 118.2 ± 57.0 0.937
Inflammatory markers
    Hs-CRP (mg/dL) 0.59 ± 1.3 0.35 ± 0.3 0.843
    TNF-α (pg/mL) 1.2 ± 0.6 1.3 ± 0.6 0.340
    IL-6 (pg/mL) 2.0 ± 1.2 2.1 ± 1.0 0.485
    LBP (μg/mL) 11.2 ± 3.5 11.2 ± 3.7 0.966
Fecal organic acids (μmol/g) and pH
    Total organic acids 94.1 ± 40.0 (100) 89.7 ± 42.9 (100) 0.600
    Acetic acid 56.1 ± 24.4 (100) 55.5 ± 25.9 (100) 0.917
    Propionic acid 19.4 ± 10.5 (100) 18.7 ± 10.4 (100) 0.790
    Butyric acid 12.6 ± 8.5 (94.6) 11.7 ± 9.1 (88.5) 0.673
    Isovaleric acid 3.7 ± 2.5 (63.0) 2.8 ± 1.5 (61.5) 0.191
    Valeric acid 3.0 ± 1.7 (47.8) 2.8 ± 1.3 (57.7) 0.965
    Succinic acid 2.7± 5.6 (56.5) 1.3 ± 1.0 (42.3) 0.779
    Lactic acid 4.3 ± 5.3 (17.4) 3.2 ± 2.8 (11.5) NA
    Formic acid 1.2 ± 1.3 (60.8) 1.2 ± 1.1 (69.2) 0.984
    pH 6.6 ± 0.7 (100) 6.6 ± 0.5 (100) 0.917

Data are expressed as mean ± SD. NA: not available, Detection rates are expressed as percentages (%). The lower limit of the measurement of fecal organic acid concentrations (μmol/g): Acetic acid 0.4, Propionic acid 0.5, Butyric acid 0.55, Isovaleric acid 0.8, Valeric acid 0.65, Succinic acid 0.08, Lactic acid 0.2, Formic acid 0.05. See Table 1 for abbreviations.