Table 1. Patients' characteristics and group comparison between patients with and without asprosin increase during hypoglycemic phase.
| Group with asprosin increase (n = 6) | Group without asprosin increase (n = 9) | ||
|---|---|---|---|
| Gender (m/f) | 3/3 | 4/5 | ns |
| Age (years) | 50.5 (30–66) | 56 (29–75) | ns |
| BMI (kg/m2) | 24.4 (20.1–31.3) | 25.4 (21–38.9) | ns |
| Smoking | 0 | 2 | ns |
| Diabetes duration (years) | 22 (12–36) | 30 (2–51) | ns |
| HbA1c (%) HbA1c (mmol / mol) |
7.0 (5.9–9.0) 53.0 (41.0–74.9) |
7.6 (6.5–8.5) 59.6 (47.5–69.4) |
ns ns |
| uACR (mg / g creatinine) | 2.1 (0.4–8.4) | 3.0 (0.7–61.3) | ns |
| NSS | 0 (0–6) | 0 (0–5) | ns |
| NDS | 0 (0–10) | 2 (0–6) | ns |
| Glucose infusion rate (ml / min) | 100 (65–140) | 60 (10–150) | p = 0.066 |
| hsCRP (mg / l) | 1.75 (0.15–12.4) | 1.86 (0.16–7.93) | ns |
| Creatinine (mg / dl) | 0.76 (0.54–1.06) | 0.78 (0.62–1.56) | ns |
| eGFR CKD-EPI (ml/min*1•73m2) | 102 (60–127) | 101 (43–122) | ns |
| AST (U / l) | 20 (13–33) | 23 (18–40) | ns |
| ALT (U / l) | 18 (7–26) | 22 (13–50) | ns |
| AST/ALT-ratio | 1.4 (0.8–2.3) | 1.1 (0.7–1.4) | ns |
| AP (U / l) | 69 (41–94) | 72 (44–94) | ns |
| GGT (U / l) | 15 (8–123) | 22 (12–53) | ns |
| Total cholesterol (mg / dl) | 167 (148–207) | 158 (124–261) | ns |
| Triglycerides | 77 (46–101) | 121 (60–175) | ns |
| Fat mass (BIA) (kg) | 16.4 (7.6–31.8) | 18.8 (9.5–42.3) | ns |
| Fat free mass (BIA) (kg) | 58.4 (43.7–72.0) | 58.5 (43.2–63.5) | ns |
| Body cell mass (BIA) (kg) | 31.6 (22.5–39.0) | 27.9 (20.4–33.0) | ns |
| Phase angle (BIA) (degrees) | 6.7 (6.1–6.9) | 5.6 (4.7–7.2) | ns |
| Glucose during clamp | |||
| hyperglycemia | 267 (212–367) | 267 (196–449) | ns |
| euglycemia | 87 (72–105) | 93 (84–97) | ns |
| hypoglycemia | 58 (47–70) | 58 (51–66) | ns |
Given are absolute numbers for gender as well as the number of smokers and median values and/or ranges for all other parameters. BMI = body mass index; HbA1c = glycated hemoglobin A1c; mmol = millimol; uACR = urinary albumin-creatinine-ratio; NSS = neuropathy symptom score; NDS = neuropathy deficit score; hsCRP = high sensitive c-reactive protein; eGFR = estimated glomerular filtration rate; CKD-EPI = Chronic Kidney Disease Epidemiology Collaboration; AST = aspartate aminotransferase; ALT = alanine aminotransferase; AP = alkaline phosphatase; GGT = gamma-glutamyl transferase; HDL = high-density lipoprotein; LDL = low-density-lipoprotein; m = male; f = female; kg = kilograms; m2 = square meters; mg = milligrams; g = grams; ml = milliliters; min = minute; mU = milliunits; l = liters; kPa = kilopascals; IQR = interquartile range; l = liters; dl = deciliters; U = units.