Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The free energy landscape as determined by 2D WHAM analysis of the umbrella sampling data on NEB determined structural evolution images along the loop open-closure conformational exchange pathway. ΔRMSD is the X coordinate and Psi356 is the Y coordinate. The two endpoint starting structures were prepared from PDBID:3U96 (Y357F mutant) according to the procedure described in Methods section. The side bar shows the color coded energy levels (kcal/mol).
