Table 1. Uni- and multivariate Cox-regression analysis of 90-day mortality.
High sCD14, sCD163, sCD206 and Osteopontin levels are significantly associated with mortality at 90 days besides other clinical factors and laboratory parameters (univariate regression), but high sCD14 is the only independent predictor (multivariate regression).
| Univariate Cox-regression | Multivariate Cox-regression | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Gender | 0.513 | 0.163–1.614 | 0.254 | |||
| Age | 1.026 | 0.97–1.084 | 0.376 | |||
| Meld score | 1.103 | 1.049–1.16 | 0.000 | 1.028 | 0.885–1.193 | 0.719 |
| Maddrey’s DF | 1.023 | 1.009–1.036 | 0.001 | 1.016 | 0.998–1.034 | 0.082 |
| Cirrhosis* | 1.358 | 0.301–6.127 | 0.691 | |||
| Ascites* | 3.949 | 1.349–11.562 | 0.012 | 0.552 | 0.138–2.213 | 0.402 |
| Encephalopathy* | 1.544 | 0.484–4.925 | 0.463 | |||
| AST | 1.007 | 1.002–1.012 | 0.009 | 1.003 | 0.996–1.010 | 0.425 |
| ALT | 1.008 | 0.993–1.022 | 0.302 | |||
| AST/ALT | 1.472 | 1.087–1.995 | 0.013 | 0.870 | 0.551–1.371 | 0.547 |
| Alk. Phos. | 1.003 | 0.999–1.006 | 0.122 | |||
| Albumin | 0.406 | 0.183–0.897 | 0.026 | 0.721 | 0.328–1.583 | 0.415 |
| WBC count | 1.058 | 1.001–1.119 | 0.046 | 1.037 | 0.960–1.121 | 0.359 |
| High sCD14 | 4.690 | 1.695–12.979 | 0.003 | 4.168 | 1.374–12.644 | 0.012 |
| High sCD163 | 8.902 | 1.170–67.729 | 0.035 | 0.989 | 0.077–12.740 | 0.993 |
| High sCD206 | 8.212 | 1.852–36.409 | 0.006 | 3.586 | 0.771–16.688 | 0.104 |
| High OPN | 13.672 | 1.796–104.075 | 0.012 | 4.535 | 0.549–37.458 | 0.160 |
HR: hazard ratio; CI: Confidence interval; DF: discriminant factor; decomp.: decompensation; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AST/ALT: AST-ALT ratio; Alk. Phos.: alkaline phosphatase; WBC: white blood cell; OPN: osteopontin.
*
present/absent.