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. 2019 Sep 19;10:4265. doi: 10.1038/s41467-019-12271-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Model of MRN function in R-loop tolerance and mitigation. a The MRN complex may play a structural role at transcription–replication conflicts upstream of FA pathway activation and genome stability maintenance. Speculative models for how the FA pathway could resolve these conflicts are indicated with question marks. b When MRN is depleted, the FA proteins are poorly recruited to transcription–replication conflicts, R-loops are stabilized, DNA is damaged and genome instability results