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. 2019 Sep 19;9:13567. doi: 10.1038/s41598-019-49729-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Mammalian cell co-culture assay with S. flexneri lux1 in the presence of ampicillin or ciprofloxacin. The luminescence of the intracellular (red square) and extracellular (blue circle) S. flexneri was measured after incubation with either ampicillin (a–c) or ciprofloxacin (d–f) for 0.5 hours (a,d), 2 hours (b,e), and 4 hours (c,f). The values of the antibiotic treated wells were normalized to wells that contained vehicle control. Values are reported as mean ± SD (n = 8). The solid line and dashed lines represent the normalized mean ± SD of the vehicle control (extracellular samples) at each time point, respectively. The vehicle control relative luminescence unit SD for extracellular and intracellular samples were similar at each time point. A black circle with a solid line represents a significantly larger reduction in luminescence generated by ciprofloxacin compared to ampicillin at the corresponding concentration. In contrast, a black circle with a dashed line represents a significantly larger reduction in luminescence generated by ampicillin compared to ciprofloxacin at the corresponding concentration.