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. 2019 Sep 19;9:13567. doi: 10.1038/s41598-019-49729-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ciprofloxacin dose response in the mouse model of Shigella infection. Previous studies have established a target ciprofloxacin AUC/MIC ratio of 250 for the treatment of Gram-negative bacterial infections in humans. The efficacy of ciprofloxacin oral doses predicted to generate AUC/MIC values ranging from 22–900 were evaluated in the mouse model of Shigella infection. In agreement with the target AUC/MIC ratio of 250, infected mice with predicted ciprofloxacin AUC/MIC values of ≤225 had detectable S. flexneri infection in the large intestine and/or small intestine. In contrast, mice receiving ciprofloxacin doses of 20 and 40 mg/kg BID (AUC/MIC ratios of 450 and 900, respectively) had no detectable S. flexneri in their gastrointestinal tissue. Values are reported as mean ± SD (n = 3 mice/group).