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. 2019 Sep 19;9:12986. doi: 10.1038/s41598-019-49364-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Repeated LV injection of liraglutide attenuates development of hypertension in SHR. Effect of repeated LV injection of 0.9 µg liraglutide or saline once a day for 15 days on systolic blood pressure (A) and heart rate (B) in SHR (n = 5) and WKY rats (n = 5–6), and systolic blood pressure (C) in liraglutide-injected SHR (n = 5) and saline-injected SHR pair-fed to liraglutide-injected group (n = 5). Data are shown as mean ± SE. *P < 0.05 between liraglutide and saline groups by repeated measures two-way ANOVA followed by Turkey’s post hoc test. Figure A (SHR): P value for time, group and time x group interaction are p < 0.0001, p = 0.0409 and p = 0.0301, respectively. Figure C: P value for time, group and time x group interaction are p < 0.0001, p = 0.7918 and p = 0.0045, respectively.