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. 2019 Sep 19;9:12986. doi: 10.1038/s41598-019-49364-x

Figure 3.

Figure 3

Repeated LV liraglutide induces c-Fos expression in AP and NTS. Distribution of c-Fos expression in the brain of SHR and WKY rats at four hours after LV injection of liraglutide on the first day of experiment (A–G, n = 5) and on the next day after termination of repeated LV injection of liraglutide for two weeks (H–N, n = 6–7). (A–F,H–M) c-Fos immunostaining in PVN, ARC and AP/NTS after LV injection of saline (left panel) or 0.9 µg liraglutide (right panel). Scale bars indicate 200 µm. 3V, third ventricle; CC, central canal. (G,N) Number of c-Fos immunoreactive (IR) neurons/section in PVN, SON, ARC, AP, NTS, RVLM and CVLM after injection of 0.9 µg liraglutide or saline. Each bar represents mean ± SE. *P < 0.05, **P < 0.01 between liraglutide and saline, #P < 0.05, ##P < 0.01 between SHR with liraglutide and WKY with liraglutide.