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. 2019 Sep 19;9:13595. doi: 10.1038/s41598-019-50084-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Comparison of miR-21 expression urinary exosomes between patients with BC and healthy controls. Exosomal miR-21 expression in BC patients is shown as relative expression based on CT value of miR-21 in 26 healthy controls. BC, breast cancer; CT, threshold cycle. (B) Comparison of MMP-1/CD63 expression in urinary exosomes between BC patients and healthy controls. (C) Comparison of miR-21 expression pre- and post-operation. (D) Comparison of MMP-1/CD63 expression pre- and post-operation. Exosomal expression of MMP-1/CD63 was based on the ratio of the expression of western blotting.