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. 2019 Sep 19;9:13536. doi: 10.1038/s41598-019-49468-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Projection of the clinical mastitis (CM) and healthy (H) milk metagenome onto KEGG pathways. The whole metagenome sequencing (WMS) reveals significant differences (p = 0.001) in functional microbial pathways. Heatmaps show the average relative abundance hierarchical clustering of the predicted KEGG Orthologs (KOs) functional pathways of the microbiome across all samples. The color bar at the bottom represents the relative abundance of putative genes. The color codes indicate the presence and completeness of each KEGG module, expressed as a value between -1 (low abundance) and 1 (high abundance). The yellow color indicates the more abundant patterns, whilst blue cells accounts for less abundant KOs in that particular sample. The color bar at the bottom represents the higher relative abundance of putative genes. Sample name: suffix ends with C refers to clinical mastitis (CM) and that ends with H refers to healthy (H) milk samples.