Fig. 3.

Global summary of between-pathway and within-pathway interactions discovered from a Parkinson’s disease cohort (PD-NIA). Network representation of a set of significant (FDR ≤ 0.25) between-pathway (BPM) and within-pathway interactions (WPM) that are associated with increased (orange edges) or decreased (green edges) risk of PD. Each node indicates the name of the pathway or gene set, and each edge represents a between-pathway interaction or within-pathway interaction (self-loop edges). The size of the node reflects the number of interactions edges it has. Replicated interactions are shown as bold lines