Fig. 1.

Correlates of global DNA methylation level. Correlation between genomic methylation levels and cell proliferation markers a, mutation burden b, aneuploidy level c, and tumour-infiltrating CD8 + T cell markers d across and within 21 cancer types. a–d The median values were obtained for each cancer type, and statistical significance was evaluated using Spearman’s correlation (upper scatterplots). Three outlier cancer types (ESCA, STAD, and UCEC) are not shown for the CD8 + T cell correlation, but included when evaluating Spearman’s correlation. For the correlation within each cancer type (lower bar graphs), Spearman’s partial correlation was used to adjust for tumour purity. Tumour types showing significant partial correlation coefficient (P < 0.05) were shaded in darker colours