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. 2019 Sep 19;9:13547. doi: 10.1038/s41598-019-49960-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of ΔNp73 and TAp73 relative mRNA expression levels in paired normal and pathological tissue samples by qPCR. (a) For ΔNp73, relative mRNA expression 2.12 ± 0.35 (mean ± SEM) was found in pathological tissue, while values of 1.05 ± 0.13 (mean ± SEM) were found in normal tissue (p-value = 0.04163). For TAp73, relative mRNA expression of 1.02 ± 0.27 (mean ± SEM) was found in pathological tissue, while values of 0.017 ± 0.002 (mean ± SEM) were found in normal tissue (p-value 1.916e-5). Trimmed mean was used in all cases to compensate for extreme values. All measurements were taken in duplicate. (b) Assessment of the predictive value of the relative mRNA expression levels for TAp73 and ΔNp73 in tissue samples of healthy individuals vs premalignant and CRC subjects was performed through ROC curves, with only TAp73 a showing significant predictive value. (c) Evaluation of the predictive value of the combination of the seroreactivity to p73, ΔNp73α, or ΔNp73β, and the mRNA expression levels of TAp73 showed an overall AUC of 71.6%.