Table 1.
Summary of statistical associations between genetic risk score and anhedonia-related markers across units of analyses (self-report, behavior, and brain circuit)
| Units of analyses | Measure | N | ΔR2 | ΔF, p value |
|---|---|---|---|---|
| Self-report | Snaith Hamilton pleasure scale score | 82 | 0.017 | 1.39, 0.24 |
| Behavior | Stress-induced changes in reward learning | 59 | 0.035 | 2.31, 0.135 |
| Circuits (functional) |
Stress-induced changes in RPE Bilateral NAc RPE (poststress–prestress) Bilateral Put RPE (poststress–prestress) |
62a 63 |
0.065 0.074 |
4.76, 0.033 5.14, 0.027 |
| Circuits (structural) |
Striatal volume Bilateral NAc volume Bilateral Put volume |
73 73 |
0.064 0.095 |
5.01, 0.028 7.32, 0.009 |
RPE reward prediction error, NAc nucleus accumbens, Put putamen
aOne participant was an outlier in stress-induced NAc activation and was omitted from the analyses