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. 2019 Sep 13;10:2196. doi: 10.3389/fimmu.2019.02196

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Copyright © 2019 Yang, Wang, Cheng, Yang, Wu, Jia, Liu, Zhu, Chen, Zhang, Zhao, Huang, Wang, Xu, Chen, Zhu, Luo, Liu, Yu, Zhang, Tian, Pan, Rehman and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MyD88, Mal, TIRAP,TIRAP-induced IFN-β and TRAM. The formation of protein complexes of unique TBK1 and IKK inhibitors leads to activation of the transcription factors IRF3 and IRF7 and induction of IFN-β expression. Viral proteins can degrade TLRs and interfere with TLR recognition. The ubiquitination activity of viral proteins can inhibit MyD88, Mal, and TRAF6. A series of strategies is used for virus immune evasion. Some inspiration for this figure was obtained from previous articles (4).