Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A schematic diagram of the pathogen-derived molecules used to escape intracellular RNA sensing pathways. The sensors in the pathway include RIG-I and MDA-5, which can detect different RNA species, primarily those containing 5′ diphosphate or triphosphate or long dsRNA, respectively. Pathogen-derived degradative or inhibitory helper proteins inhibit RIG-I activation through direct binding to block the interaction between RIG-I and MAVS and prevent RIG-I from entering mitochondria.
