Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Tegument proteins that inhibit the TLR pathway.
| Protein | Virus | Function | References |
|---|---|---|---|
| RL2 (ICP0) | HSV-1 | Reduces the inflammatory response triggered by TLR2 | (48) |
| Decreases MyD88 and Mal | (49) | ||
| US3 | HSV-1 | Reduces the levels of TLR3 and type I IFNs | (50) |
| Inhibits TLR2 signaling by reducing TRAF6 polyubiquitination | (51) | ||
| UL41 | HSV-2 | Reduces the expression of TLR2 and TLR3 | (52) |
