Table 4.

Tegument proteins that inhibit the NF-κB pathway.

Protein	Virus	Function	References
UL48 (VP16)	HSV-1	Inhibits NF-κB activation and interferes with the IRF-3-mediated recruitment of its coactivator CBP	(91)
ORF61	SVV	Prevents IκBα ubiquitination and interacts with β-TrCP	(92)
	VZV	Inhibits TNF-α-induced NF-κB reporter activity	(93)
RL2 (ICP0)	HSV-1	Interacts with p50 and p60 and degrades the proteasomal protein p50	(94)
US3	HSV-1	Ubiquitinates IκBα	(95)
		Hyperphosphorylates p65 at serine 75 and blocks p65 nuclear translocation	(97)