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. 2019 Sep 13;10:2196. doi: 10.3389/fimmu.2019.02196

Table 5.

Tegument proteins that inhibit the DNA sensor signaling pathway.

Protein Virus Function References
RL2 (ICP0) HSV-1 Targets IFI16 degradation, inhibiting additional signaling and IRF-3 activation (99)
Blocks STING and the transcription factor IRF3 (100102)
UL49 (VP22) HSV-1 Inhibits the enzymatic activity of cGAS (103)
UL46 (VP11-12) HSV-1 Blocks STING and IFI16 transcript accumulation (104)
UL37 HSV-1 Deamidates cGAS proteins (105)
UL54 (ICP27) HSV-1 Targets the TBK1-activated STING signalsome (106)