Table 5.
Tegument proteins that inhibit the DNA sensor signaling pathway.
| Protein | Virus | Function | References |
|---|---|---|---|
| RL2 (ICP0) | HSV-1 | Targets IFI16 degradation, inhibiting additional signaling and IRF-3 activation | (99) |
| Blocks STING and the transcription factor IRF3 | (100–102) | ||
| UL49 (VP22) | HSV-1 | Inhibits the enzymatic activity of cGAS | (103) |
| UL46 (VP11-12) | HSV-1 | Blocks STING and IFI16 transcript accumulation | (104) |
| UL37 | HSV-1 | Deamidates cGAS proteins | (105) |
| UL54 (ICP27) | HSV-1 | Targets the TBK1-activated STING signalsome | (106) |