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CCR7 homology model. (A) Structural link between ECL-2 and extracellular part of TM3 (B) entrance to the minor binding pocket. The CCR5-based homology model of CCR7 was built in the Molsoft ICM program (PDB ID 4MBS). R54N−term, W1142.60, K1303.26, C1293.25, D198ECL−2, R209ECL2, and C210ECL−2 are shown in stick representations. Dotted lines represent potential long-range charge-charge interaction between K1303.26 and D198ECL−2.
