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. 2019 Sep 13;10:2156. doi: 10.3389/fimmu.2019.02156

Figure 6.

Figure 6

Signaling events at CCR7 rely on core domain interactions and ECL-2 of CCR7. (A) Chemokine cores determine differential signaling by CCL21 and CCL19. Chemokines containing the core of CCL19 display G protein signaling and β-arrestin-2 recruitment, whereas chemokines containing the core of CCL21 display G protein signaling but fail to recruit β-arrestin-2. (B) The current mutagenesis study of CCR7 shows that especially the extracellular events are important for chemokine signaling at CCR7, and the figure highlights ECL-2, which was found to play an important but differential role during interactions with the two chemokines. (C) The current study also found a lysine in TM3, K1303.26, to be important for regulating signaling, as the alanine substitution of this residue selectively impaired G protein signaling while not showing an effect on β-arrestin-2 recruitment upon CCR7 stimulation.