TABLE 3.
Renal functional data in BUO, B-R1D, and B-R3D mice with or without aliskiren treatment.
| Sham | BUO | BUO + Ali | Sham | B-R1D | B-R1D + Ali | Sham | B-R3D | B-R3D + Ali | |
| BW (g) | 22.5 ± 1.0 | 22.5 ± 0.6 | 22.8 ± 0.5 | 22.0 ± 0.8 | 22.7 ± 0.6 | 22.4 ± 0.5 | 21.2 ± 0.4 | 21.6 ± 0.3 | 20.5 ± 0.5 |
| PK (mmol/L) | 3.3 ± 0.09 | 5.8 ± 0.33∗ | 5.5 ± 0.15∗ | 3.5 ± 0.05 | 4.5 ± 0.48∗ | 4.6 ± 0.34∗ | 3.5 ± 0.04 | 3.7 ± 0.02 | 4.3 ± 0.04∗# |
| CCr (μL/min/g bw) | 4.93 ± 1.03 | 2.27 ± 0.51∗ | 2.70 ± 0.20∗ | 4.91 ± 0.13 | 4.32 ± 0.54 | 3.67 ± 0.20 | |||
| UO (μl/24 h/g bw) | 34.0 ± 4.7 | 241.1 ± 9.7∗ | 206.4 ± 10.9∗# | 48.2 ± 5.2 | 155.7 ± 10.2∗ | 103.7 ± 14.1∗# | |||
| UOsm (mOsm/kg⋅H2O) | 2403 ± 244 | 413 ± 19∗ | 531 ± 26∗# | 2684 ± 321 | 1215 ± 103∗ | 1333 ± 135∗ |
BW, body weight; PK, plasma potassium; CCr, creatinine clearance rate; UO, urine output; UOsm, urine osmolality; Sham, sham-operated groups; BUO, bilateral ureteral obstruction for 24 h; B-R1D, bilateral ureteral obstruction for 16 h followed by 1 day release; B-R3D, bilateral ureteral obstruction for 16 h followed by 3 days release. ∗p < 0.05 compared with Sham group; #p < 0.05 compared with obstructed kidney group.