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. 2019 Sep 19;9:13592. doi: 10.1038/s41598-019-50018-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of anisomycin on epileptiform activity elicited by 4-AP in acute hippocampal slices of 3-month-old WT and Tg2576 mice. (A) Representative traces of extracellular field recordings in acute hippocampal slices of 3-month-old WT mice before 4-AP addition (top), in the presence of 50 μM 4-AP alone (middle) and in the presence of 100 μM anisomycin (bottom). (B) Representative traces of extracellular field recordings in acute hippocampal slices of 3-month-old Tg2576 mice before 4-AP addition (top), in the presence of 50 μM 4-AP alone (middle) and in the presence of 100 μM anisomycin (bottom). (C) Quantification of frequency (Hz), interval (sec), and amplitude (mV) of extracellular field recordings in acute hippocampal slices of 3-month-old WT and Tg2576 mice under control conditions. *p < 0.05 versus WT (D) Quantification of 4-AP-induced epileptiform activity, as frequency (Hz), interval (sec), and amplitude (mV), in the presence of 100 μM anisomycin, in acute hippocampal slices of 3-month-old WT and Tg2576 mice. Values are expressed as a percentage of basal values measured in the presence of 4-AP alone before starting the perfusion with anisomycin. *p < 0.05 versus WT.