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. 2019 Sep 13;9:890. doi: 10.3389/fonc.2019.00890

Figure 4.

Figure 4

SCNE and NIM inhibits OSCC derived tumor growth in mice and reduces inflammatory cytokines. (A–C) SCNE supplementation (200 mg/kg) of the AIN76A diet significantly inhibited tumor growth in OSCC mouse xenografted models; [(A): SCC4−30 day treatment yielded−81.12% reduction in tumor volumes; (B): Cal27−35 day treatment yielded−49.00% reduction in tumor volume; and (C): HSC3−25 day treatment yielded−48.81% reduction in tumor volumes] (*p < 0.005, **p < 0.001). (C) NIM treatment (20 mg/kg IP) significantly reduced HSC3 tumor volumes (66%; *p < 0.05) in mice after 25 days. (D,E) SCNE produces M1 phenotype in TAMs. (F) Inflammatory cytokine levels from SCC4, Cal27, and HSC3 xenografted mice are reduced when fed SCNE (200 mg/kg) in diet and IP injected NIM.