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. 2019 Sep 20;39(9):BSR20190159. doi: 10.1042/BSR20190159

Figure 8. Effect of P13K/AKT or ERK overexpression on EMT in A549 cells.

Figure 8

(A) Effects of overexpression of PI3K/Akt on the protein expression of E-cadherin, N-cadherin, vimentin, phospho-Akt, and Akt of A549 lung cancer cells. (B) Quantitative result of E-cadherin, N-cadherin, vimentin, phospho-Akt, and Akt proteins expression of A549 lung cancer cells transfected with pcDNA3.1(+)-Akt or pcDNA3.1 vector. (C) Effects of overexpression of ERK on the protein expression of E-cadherin, N-cadherin, vimentin, phospho-ERK1/2, and ERK1/2 of A549 lung cancer cells. (D) Quantitative result of E-cadherin, N-cadherin, vimentin, phospho-ERK1/2, and ERK1/2 proteins expression of A549 lung cancer cells transfected with pcDNA3.1(+)-ERK or pcDNA3.1 vector. Bars represent mean ± S.D. (n=3). *P<0.05, **P<0.01, and ***P<0.001 were considered to indicate a statistically significant difference compared with the normal control. #P<0.05, ##P<0.01, and ###P<0.001 were considered to indicate a statistically significant difference compared with the Isorhamnetin (10 μM)-treated control.