Table 1. Baseline Characteristics of Patients according to Expression Status Related to Shh Pathway.
| Variables | Patient number (%) | Shh | p value | Gli1 | p value | Patched | p value | Smo | p value | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes (n=5) | No (n=31) | Yes (n=12) | No (n=24) | Yes (n=5) | No (n=31) | Yes (n=6) | No (n=30) | ||||||
| Median age in years (range) | 65 (49–75) | 65 (49–75) | 66 (50–75) | 0.810 | 66 (50–75) | 65 (49–75) | 0.797 | 65 (51–68) | 67 (49–75) | 0.431 | 61 (57–68) | 67 (49–75) | 0.587 |
| Sex | 0.084 | 0.588 | 0.084 | 0.535 | |||||||||
| Male | 32 (88.9) | 3 (60.0) | 29 (93.5) | 10 (83.3) | 22 (91.7) | 3 (60.0) | 29 (93.5) | 5 (83.3) | 27 (90.0) | ||||
| Female | 4 (11.1) | 2 (40.0) | 2 (6.5) | 2 (16.7) | 2 (8.3) | 2 (40.0) | 2 (6.5) | 1 (16.7) | 3 (10.0) | ||||
| ECOG | 0.571 | 0.655 | >0.999 | 0.655 | |||||||||
| 0 | 10 (27.8) | 1 (20.0) | 9 (29.0) | 4 (33.3) | 6 (25.0) | 1 (20.0) | 9 (29.0) | 1 (16.7) | 9 (30.0) | ||||
| ≥1 | 26 (72.2) | 4 (80.0) | 22 (71.0) | 8 (66.7) | 18 (75.0) | 4 (80.0) | 22 (71.0) | 5 (83.3) | 21 (70.0) | ||||
| Metastasis | |||||||||||||
| Brain | 7 (20.0) | 1 (20.0) | 6 (19.4) | >0.999 | 0 (0.0) | 7 (29.2) | 0.072 | 1 (20.0) | 6 (19.4) | >0.999 | 0 (0.0) | 7 (23.3) | 0.311 |
| Liver | 9 (25.7) | 2 (40.0) | 7 (22.6) | 0.586 | 3 (25.0) | 6 (25.0) | >0.999 | 4 (80.0) | 5 (16.1) | 0.010 | 2 (33.3) | 7 (23.3) | 0.635 |
| Lung | 8 (22.9) | 0 (0.0) | 8 (25.8) | 0.315 | 3 (25.0) | 5 (20.8) | 0.685 | 0 (0.0) | 8 (25.8) | 0.315 | 2 (33.3) | 6 (20.0) | 0.602 |
| Bone | 13 (37.1) | 3 (60.0) | 10 (32.3) | 0.337 | 4 (33.3) | 9 (37.5) | >0.999 | 4 (80.0) | 9 (29.0) | 0.052 | 3 (50.0) | 10 (33.3) | 0.648 |
| P.E. | 15 (42.9) | 2 (40.0) | 13 (41.9) | >0.999 | 6 (50.0) | 9 (37.5) | 0.467 | 0 (0.0) | 15 (48.4) | 0.057 | 4 (66.7) | 11 (36.7) | 0.367 |
| P.C.E. | 3 (8.6) | 0 (0.0) | 3 (9.7) | >0.999 | 1 (8.3) | 2 (8.3) | >0.999 | 0 (0.0) | 3 (9.7) | >0.999 | 0 (0.0) | 3 (10.0) | >0.999 |
Shh, sonic hedgehog; Gli1, glioma-associated oncogene homolog zinc finger protein 1; Smo, Ptch-mediated repression of smoothened; ECOG, Eastern Cooperative Oncology Group; P.E., pleural effusion; P.C.E., pericardial effusion.
Values are presented as median (range) or n (%) unless otherwise indicated.