Fig. 1. Longitudinal Clinical Dementia Rating sum of boxes (CDR-SOB) score changes according to beta-amyloid positivity. The number of subjects at baseline was 230 and 268 for amnestic mild cognitive impairment with low Aβ burden (aMCI Aβ−) and amnestic mild cognitive impairment with high Aβ burden (aMCI Aβ+), respectively. The number of subjects at 1-year follow-up (FU) was 156 and 253 for aMCI Aβ− and aMCI Aβ+, respectively. The number of subjects at 5-year FU was 52 and 68 for aMCI Aβ− and aMCI Aβ+, respectively. ^*p<0.01; ^†p<0.001.